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L-659989 _Molecular_structure_CAS_113787-28-3)
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L-659989

Catalog No. L009500 Name Toronto Research Chemicals
CAS Number 113787-28-3 Website http://www.trc-canada.com
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SYNONYMS

IUPAC name
(2S,5S)-2-(3-methanesulfonyl-5-methoxy-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolane
IUPAC Traditional name
(2S,5S)-2-(3-methanesulfonyl-5-methoxy-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolane
Synonyms
(2R,5R)-rel-Tetrahydro-2-[3-methoxy-5-(methylsulfonyl)-4-propoxyphenyl]-5-(3,4,5-trimethoxyphenyl)furan
trans-(±)-Tetrahydro-2-[3-methoxy-5-(methylsulfonyl)-4-propoxyphenyl]-5-(3,4,5-trimethoxyphenyl)furan
L 659989

DATABASE IDS

CAS Number 113787-28-3

PROPERTIES

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DETAILS

Description (English)
L-659989 is a platelet-activating factor (PAF) receptor antagonist. L-659989 is also a potent inhibitor of phospholipase D activity at higher concentrations. L-659989 showed cardioprotective effects as it inhibited heart injury from ischemia and reperfusi

REFERENCES

  • Hussaini, I.M. et al.: Acta Pharmacol. Sin., 21, 897 (2000)
  • Gomez-M. et al.: Biochim. Biophys. Acta, 1438, 247 (2000)
  • Ioculano, M. et al.: J. Cardio. Pharmacol., 23, 7 (2000)