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Kifunensine

Catalog No. K450000 Name Toronto Research Chemicals
CAS Number 109944-15-2 Website http://www.trc-canada.com
M. F. C8H12N2O6 Telephone +1 (416) 665-9696
M. W. 232.19068 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage -20°C Freezer Chembase ID: 172134

SYNONYMS

IUPAC name
(5R,6R,7S,8R,8aS)-6,7,8-trihydroxy-5-(hydroxymethyl)-octahydroimidazolidino[1,2-a]pyridine-2,3-dione
IUPAC Traditional name
(5R,6R,7S,8R,8aS)-6,7,8-trihydroxy-5-(hydroxymethyl)-hexahydroimidazolidino[1,2-a]pyridine-2,3-dione
Synonyms
FR 900494
[5R-(5α,6β,7α,8α,8aα)]-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
(+)-Kifunensine

DATABASE IDS

CAS Number 109944-15-2

PROPERTIES

Certificate of Analysis Download
Apperance White Solid
Melting Point >280°C (dec.)
Solubility DMSO
Solubility Hot Water
MSDS Link Download
Storage Condition -20°C Freezer
Storage Warning Desiccate and Store at -20°C

DETAILS

Description (English)
Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme

REFERENCES

  • Kayakiri, H., et al.: Chem. Pharm. Bull., 39(1987)
  • 1378 (1991)
  • Iwami, M., et al.: J. Antibiotic., 40, 612 (1987)
  • Elbein, A.D., et al.: J. Biol. Chem., 265, 15599 (1987)
  • Elbein, A.D., et al.: Archives of Biochem & Biophys., 288, 1, 177 (1987)