Ketoconazole-d8

• Catalog No.: K186002
• M. F.: C26H28Cl2N4O4
• M. W.: 531.43092
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)(^2H₈)piperazin-1-yl]ethan-1-one
• IUPAC Traditional name: 1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)(^2H₈)piperazin-1-yl]ethanone
• Synonyms: cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine-d8

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 140-144°C
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: DMSO
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Deuterated Ketoconazole, an inhibitor of cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.

REFERENCES

• Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986)
• Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1986)
• Nardone, P.A., et al.: . Surg. Res., 44, 425 (1986)
• Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)