Ketoconazole

• Catalog No.: K186000
• CAS Number: 65277-42-1
• M. F.: C26H28Cl2N4O4
• M. W.: 531.43092
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
• IUPAC Traditional name: (2R,4S)-ketoconazole
• Synonyms: R 41400; Onofin K; Orifungal M; rel-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone; Nizoral; cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; (+/-)-Ketoconazole; Brizoral; Fungarest; Fungoral; Ketoderm; Ketoisdin; Ketozoral; Nizral; Panfungol

DATABASE IDS

• CAS Number: 65277-42-1

PROPERTIES

• Apperance: White Solid
• Melting Point: 144-146°C
• Solubility: Chloroform
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.

REFERENCES

• Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986)
• Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1986)
• Nardone, P.A., et al.: . Surg. Res., 44, 425 (1986)
• Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)