3-Keto-N-aminoethyl-N'-aminocaproyldihydrocinnamoyl Cyclopamine, >80%

• Catalog No.: K171000
• CAS Number: 306387-90-6
• M. F.: C44H63N3O4
• M. W.: 697.98872
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: N-{2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxo-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3'H-spiro[cyclohexa[a]fluorene-9,2'-furo[3,2-b]pyridine]-4'-yl]ethyl}-6-(3-phenylpropanamido)hexanamide
• IUPAC Traditional name: N-{2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxo-1,2,3',3'a,4,5',6,6',6a,6b,7,7',7'a,8,11,11a-hexadecahydrospiro[cyclohexa[a]fluorene-9,2'-furo[3,2-b]pyridine]-4'-yl]ethyl}-6-(3-phenylpropanamido)hexanamide
• Synonyms: KAAD-Cyclopamine

DATABASE IDS

• CAS Number: 306387-90-6

PROPERTIES

• Apperance: Pale Yellow Solid
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1 The KAAD-Cyclopamine has shown 10-20 fold higher potency than cyclopamine in inhibition of β-Galactosidase expression in p2Ptch-1- cells, with similar or lower toxicity. KAAD-Cyclopamine compound is unstable in solution.

REFERENCES

• Taipale, J., et al.: Nature, 406, 1005 (2000)
• Perron, M., et al.: Development, 130, 1565 (2000)