Kenpaullone

• Catalog No.: K162500
• CAS Number: 142273-20-9
• M. F.: C16H11BrN2O
• M. W.: 327.17534
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 14-bromo-8,18-diazatetracyclo[9.7.0.0^2,^7.0^1^2,^1^7]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
• IUPAC Traditional name: 14-bromo-8,18-diazatetracyclo[9.7.0.0^2,^7.0^1^2,^1^7]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
• Synonyms: 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; 9-Bromopaullone; NSC 664704

DATABASE IDS

• CAS Number: 142273-20-9

PROPERTIES

• Apperance: Dark Yellow Solid
• Melting Point: >300°C (dec.)
• Solubility: DMSO
• Solubility: Ethyl Acetate
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

The paullones are a novel class of kinase inhibitors, initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3β inhibitor (IC50=23nM).

REFERENCES

• Zaharevitz, D.W., et al.: Cancer Res., 59, 2566 (1999)
• Leclerc, S., et al.: J. Biol. Chem., 276, 251 (1999)
• Bain, J., et al.: Biochem. J., in press.