IWP-2

• Catalog No.: I941600
• CAS Number: 686770-61-6
• M. F.: C22H18N4O2S3
• M. W.: 466.59892

SYNONYMS

• IUPAC name: N-(6-methyl-1,3-benzothiazol-2-yl)-2-({4-oxo-3-phenyl-3H,4H,6H,7H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide
• IUPAC Traditional name: N-(6-methyl-1,3-benzothiazol-2-yl)-2-({4-oxo-3-phenyl-6H,7H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide
• Synonyms: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide

DATABASE IDS

• CAS Number: 686770-61-6

DETAILS

Description (English)

IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. IWP-2 is useful in the treatment diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.

REFERENCES

• Poss, K., et al.: Dev. Biol., 222, 347 (2000)
• Tanaka, K., et al.: Eur. J. Biochem., 267, 4300 (2000)
• Clevers, H., et al.: Cell, 2006, 127, 469 (2000)