Itraconazole-d5

• Catalog No.: I937502
• M. F.: C35H38Cl2N8O4
• M. W.: 705.63342
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 1-[(3,3,4,4,4-^2H₅)butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
• IUPAC Traditional name: 2-[(3,3,4,4,4-^2H₅)butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-1,2,4-triazol-3-one
• Synonyms: R-51211-d5; Itrizole-d5; Triasporin-d5; Sporanox-d5; (+/-)-4-[4-[4-[4-[[(2R,4S)-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl-d5)-3H-1,2,4-triazol-3-one; Oriconazole-d5; Sporamelt-d5

PROPERTIES

• Apperance: Off-White to Beige Solid
• Melting Point: 163-165°C
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

An isotopically labelled, orally active antimycotic structurally related to Ketoconazole.A representative lot was 88% d5, 12% d4 with no d0.

REFERENCES

• Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984)
• Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1984)
• Sugar, A.M., et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1984)