Isodemecolcine

• Catalog No.: I814125
• CAS Number: 4702-33-4
• M. F.: C21H25NO5
• M. W.: 371.4269

SYNONYMS

• IUPAC name: (10S)-3,4,5,13-tetramethoxy-10-(methylamino)tricyclo[9.5.0.0^2,^7]hexadeca-1(11),2(7),3,5,12,15-hexaen-14-one
• IUPAC Traditional name: (10S)-3,4,5,13-tetramethoxy-10-(methylamino)tricyclo[9.5.0.0^2,^7]hexadeca-1(11),2(7),3,5,12,15-hexaen-14-one
• Synonyms: Isocolchicine; (S)-6,7-Dihydro-1,2,3,9-tetramethoxy-7-(methylamino)-benzo[a]heptalen-10(5H)-one

DATABASE IDS

• CAS Number: 4702-33-4

PROPERTIES

• Apperance: Yellow Solid
• Solubility: Chloroform
• Solubility: Dichlormethane
• Solubility: DMSO
• Solubility: Ethanol
• Solubility: Ethyl Acetate
• Solubility: Methanol

DETAILS

Description (English)

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pa

REFERENCES

• Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
• Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
• Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)
• Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
• Jordan, A., et al.: Med. Res. Rev