Isavuconazole-d4

• Catalog No.: I777832
• M. F.: C22H17F2N5OS
• M. W.: 437.4650864

SYNONYMS

• IUPAC name: 4-{2-[(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl}(^2H₄)benzonitrile
• IUPAC Traditional name: 4-{2-[(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl}(^2H₄)benzonitrile
• Synonyms: RO 0094815-d4; BAL 4815-d4; 2R,3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol-d4; 4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile-d4

DETAILS

Description (English)

Labelled Isavuconazole (I777832). It is a new triazole currently undergoing phase III clinical trials. This compound has shown in vitro activity against a large number of clinical important yeasts and molds including Aspergillus spp., Fusarium spp., Scedo

REFERENCES

• Ohwada, J., et al.: Bioorg. Med. Chem. Lett., 13, 191 (2003)
• Guinea, J., et al.: Antimicrob. Agents Chemother., 52, 1396 (2008)