rac-Irofulven

• Catalog No.: I769490
• CAS Number: 187277-46-9
• M. F.: C15H18O3
• M. W.: 246.30162

SYNONYMS

• IUPAC name: 6'-hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethyl-6',7'-dihydrospiro[cyclopropane-1,5'-indene]-7'-one
• IUPAC Traditional name: 6'-hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethylspiro[cyclopropane-1,5'-indene]-7'-one
• Synonyms: (+/-)-Hydroxymethylacylfulvene; 6'-Hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one

DATABASE IDS

• CAS Number: 187277-46-9

DETAILS

Description (English)

rac-Irofulven is a semi-synthetic antitumor agent derived from Illudin S. Inhibits DNA synthesis and induces apoptosis in tumor cells. Antineoplastic.

REFERENCES

• Woynarowski, J.M., et al.: Biochem. Pharmacol., 54, 1181 (1997)
• Alexandre, J., et al.: Clin. Cancer Res., 10, 3377 (1997)
• Senzer, N., et al.: Am. J. Clin. Oncol., 28, 36 (1997)