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Irinotecan Lactone Impurity _Molecular_structure_CAS_143490-53-3)
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Irinotecan Lactone Impurity

Catalog No. I767520 Name Toronto Research Chemicals
CAS Number 143490-53-3 Website http://www.trc-canada.com
M. F. C32H36N4O5 Telephone +1 (416) 665-9696
M. W. 556.65204 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Chembase ID: 171746

SYNONYMS

IUPAC name
5,13-diethyl-7,9-dioxo-6-oxa-10,20-diazapentacyclo[10.8.0.02,10.04,8.014,19]icosa-1(20),2,4(8),12,14,16,18-heptaen-16-yl 4-(piperidin-1-yl)piperidine-1-carboxylate
IUPAC Traditional name
5,13-diethyl-7,9-dioxo-6-oxa-10,20-diazapentacyclo[10.8.0.02,10.04,8.014,19]icosa-1(20),2,4(8),12,14,16,18-heptaen-16-yl 4-(piperidin-1-yl)piperidine-1-carboxylate
Synonyms
[1,4'-Bipiperidine]-1'-carboxylic Acid 3,10-Diethyl-11,13-dihydro-1,13-dioxo-1H,3H- furo[3',4':6,7]indolizino[1,2-b]quinolin-8-yl Ester

DATABASE IDS

CAS Number 143490-53-3

PROPERTIES

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DETAILS

Description (English)
A lactone impurity of Irinotecan (I767500), a DNA topoisomerase inhibitor. A photodegradation product of a camptothecin derivative used as an anticancer drug.

REFERENCES

  • Akimoto, K. et al.: J. Chrom. 734, 401 (1996)
  • Kunimoto, T., et al.: Cancer Res., 47, 5944 (1996)
  • Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1996)
  • Chen, A., et al.: Annu. Rev. Pharmacol. Toxicol., 34, 191 (1996)