IQ 1

• Catalog No.: I748570
• CAS Number: 331001-62-8
• M. F.: C21H22N4O2
• M. W.: 362.42498

SYNONYMS

• IUPAC name: 2-[(E)-2-(4-acetylphenyl)diazen-1-yl]-2-[(1E)-3,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-1-ylidene]acetamide
• IUPAC Traditional name: 2-[(E)-2-(4-acetylphenyl)diazen-1-yl]-2-[(1E)-3,3-dimethyl-2,4-dihydroisoquinolin-1-ylidene]acetamide
• Synonyms: 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide; 2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide

DATABASE IDS

• CAS Number: 331001-62-8

DETAILS

Description (English)

IQ 1 disrupts Wnt signaling. IQ-1 in conjunction with Wnt3a has been shown to be sufficient to maintain murine embryonic stem cell proliferation in the absence of serum. Binds to the PR72/PR130 subunit of protein phosphatase PP2A preventing β-catenin from

REFERENCES

• Kanai., et al.: The Pharmacogenomics J., 4, 336 (2004)
• Miki., et al.: Stem Cells, 23, 1549 (2004)
• T. Miyabayashi, et al.: Proc. Natl. Acad. Sci., 104, 5668 (2004)
• Luo., et al.: Ann. Neurol., 65, 520 (2004)