Indomethacin Acyl-β-D-glucuronide

• Catalog No.: I641010
• CAS Number: 75523-11-4
• M. F.: C25H24ClNO10
• M. W.: 533.91176
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (2R,3R,4R,5S,6R)-6-({2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
• IUPAC Traditional name: (2R,3R,4R,5S,6R)-6-({2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
• Synonyms: 1-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate] β-D-Glucopyranuronic Acid; Indomethacin Glucuronide

DATABASE IDS

• CAS Number: 75523-11-4

PROPERTIES

• Apperance: Light-Green Solid
• Melting Point: 82-84°C
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Indomethacin Acyl-β-D-glucuronide is a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.

REFERENCES

• Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995)
• Gamage, N., et al.: Toxicol. Sci., 90, 5 (1995)
• Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (1995)
• Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (1995)