Imatinib (Pyridine)-N-oxide

• Catalog No.: I268010
• CAS Number: 571186-92-0
• M. F.: C29H31N7O2
• M. W.: 509.60214
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 3-{2-[(2-methyl-5-{4-[(4-methylpiperazin-1-yl)methyl]benzamido}phenyl)amino]pyrimidin-4-yl}pyridin-1-ium-1-olate
• IUPAC Traditional name: 3-{2-[(2-methyl-5-{4-[(4-methylpiperazin-1-yl)methyl]benzamido}phenyl)amino]pyrimidin-4-yl}pyridin-1-ium-1-olate
• Synonyms: CGP 72383; N-[4-Methyl-3-[[4-(1-oxido-3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]benzamide

DATABASE IDS

• CAS Number: 571186-92-0

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: 226-236°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

matinib (Pyridine)-N-oxide is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity A.

REFERENCES

• Dagher, R., et al.: Clin. Cancer Res., 8, 3034 (2002)
• Chourasia, M., et al.: J. Pharm. Pharm. Sci., 6, 33 (2002)
• Deininger, M., et al.: J. Clin. Oncol., 21, 1637 (2002)
• Gschwind, H., et al.: Drug Metab. Dispos., 33, 1503 (2002)