Imatinib (Piperidine)-4-oxide

• Catalog No.: I268000
• CAS Number: 571186-91-9
• M. F.: C29H31N7O2
• M. W.: 509.60214
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: 1-methyl-4-({4-[(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)carbamoyl]phenyl}methyl)piperazin-1-ium-1-olate
• IUPAC Traditional name: 1-methyl-4-({4-[(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)carbamoyl]phenyl}methyl)piperazin-1-ium-1-olate
• Synonyms: CGP 71422; 4-[(4-Methyl-4-oxido-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide

DATABASE IDS

• CAS Number: 571186-91-9

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: 146-149°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Imatinib (Piperidine)-4-oxide is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity D.

REFERENCES

• Dagher, R., et al.: Clin. Cancer Res., 8, 3034 (2002)
• Chourasia, M., et al.: J. Pharm. Pharm. Sci., 6, 33 (2002)
• Deininger, M., et al.: J. Clin. Oncol., 21, 1637 (2002)
• Gschwind, H., et al.: Drug Metab. Dispos., 33, 1503 (2002)