Iloprost-d4

• Catalog No.: I267302
• M. F.: C22H32O4
• M. W.: 360.48708

SYNONYMS

• IUPAC name: 5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]-octahydropentalen-2-ylidene](2,2,3,3-^2H₄)pentanoic acid
• IUPAC Traditional name: 5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]-hexahydro-1H-pentalen-2-ylidene](2,2,3,3-^2H₄)pentanoic acid
• Synonyms: Endoprost-d4; (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]pentanoic Acid-d4; ZK 36374-d4; (1S,2R,3R,5S)-7-[(E)-4-Carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-bicyclo[3.3.0]octane-d4; Ciloprost-d4; Ilomedin-d4

DETAILS

Description (English)

A labelled synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). Iloprost inh

REFERENCES

• Zamudio, T.P.: Arch. Cardiol. Mex., 77, 198 (2007)
• Lai, Y. et al.: Am. J. Resp. Crit. Care Med., 178, 188 (2007)
• Scorza, R. et al.: J. Rheutamol., 24, 1944 (2007)
• Melillo, E. et al.: Int. J. Microcircul. Clin. Exp., 15, 60 (2007)