Ilepatril

• Catalog No.: I266500
• CAS Number: 473289-62-2
• M. F.: C22H28N2O5S
• M. W.: 432.53312

SYNONYMS

• IUPAC name: (2R,6R,9S)-9-[(2S)-2-(acetylsulfanyl)-3-methylbutanamido]-8-oxo-7-azatricyclo[9.4.0.0^2,^7]pentadeca-1(11),12,14-triene-6-carboxylic acid
• IUPAC Traditional name: (2R,6R,9S)-9-[(2S)-2-(acetylsulfanyl)-3-methylbutanamido]-8-oxo-7-azatricyclo[9.4.0.0^2,^7]pentadeca-1(11),12,14-triene-6-carboxylic acid
• Synonyms: AVE-7688; (4S,7S,12bR)-7-[[(2S)-2-(Acetylthio)-3-methyl-1-oxobutyl]amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxo-pyrido[2,1-a][2]benzazepine-4-carboxylic Acid

DATABASE IDS

• CAS Number: 473289-62-2

DETAILS

Description (English)

A dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, for the potential treatment of hypertension and diabetic nephropathy. Ilepatril is currently in phase IIb/III clinical trials for hypertension and phase II trials for diabetic nephr

REFERENCES

• Tabrizchi, R., et al.: Drugs, 63, 2185 (2003)
• Azizi, M., et al.: Clin. Pharmacol. Ther., 79 49 (2003)
• Davidson, E., et al.: Diabetes, 56, 355 (2003)
• Del Colle, S., et al.: J. Cardiovasc. Pharmacol., 50, 487 (2003)