iCRT-14_Molecular_structure_CAS_677331-12-3)

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iCRT-14
Catalog No.	I163900	Name	Toronto Research Chemicals
CAS Number	677331-12-3	Website	http://www.trc-canada.com
M. F.	C21H17N3O2S	Telephone	+1 (416) 665-9696
M. W.	375.44358	Fax	+1 (416) 665-4439
Purity		Email	info@trc-canada.com
Storage		Chembase ID: 153301

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SYNONYMS

IUPAC name

(5Z)-5-{[2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl]methylidene}-3-phenyl-1,3-thiazolidine-2,4-dione

IUPAC Traditional name

(5Z)-5-{[2,5-dimethyl-1-(pyridin-3-yl)pyrrol-3-yl]methylidene}-3-phenyl-1,3-thiazolidine-2,4-dione

Synonyms

iCRT 14

iCRT14

5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione

DATABASE IDS

CAS Number

677331-12-3

PROPERTIES

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DETAILS

Description (English)

A potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-

REFERENCES

Gonsalves, F.C. et al.: Proc. Natl. Acad. Sci. USA, 108, 5954 (2011)
Watanabe, K. et al.: Proc. Natl. Acad. Sci. USA, 108, 5929 (2011)