Hymenialdisine-d4

• Catalog No.: H998002
• CAS Number: 1185240-30-5
• M. F.: C11H10BrN5O2
• M. W.: 324.1334

SYNONYMS

• IUPAC name: 2-amino-5-[2-bromo-8-oxo(5,5,6,6-^2H₄)-1H,4H,5H,6H,7H,8H-pyrrolo[2,3-c]azepin-4-ylidene]-4,5-dihydro-1H-imidazol-4-one
• IUPAC Traditional name: 2-amino-5-[2-bromo-8-oxo(5,5,6,6-^2H₄)-1H,7H-pyrrolo[2,3-c]azepin-4-ylidene]-1H-imidazol-4-one
• Synonyms: (Z)-Hymenialdisine-d4; (4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-pyrrolo[2,3-c]azepin-8(1H)-one-d4

DATABASE IDS

• CAS Number: 1185240-30-5

DETAILS

Description (English)

A potent inhibitor of a variety of kinases including MEK-1, GSK-3Β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations. A marine sponge alkaloid, a natural product.

REFERENCES

• Cheetham, G., et al.: J. Biol. Chem., 277, 42419 (2002)
• Bain, J., et al.: Biochem. J., 371, 199 (2002)
• Sharma, V., et al.: Bioorg. Med. Chem. Lett., 14, 4319 (2002)
• Anamika, et al.: Proteins, 58, 180 (2002)
• Birault, V., et al.: Curr. Med. Chem., 13, 1