Hymenialdisine Methanoate

• Catalog No.: H998000
• CAS Number: 84094-94-0
• M. F.: C12H14BrN5O3
• M. W.: 356.17526
• Storage: Freezer

SYNONYMS

• IUPAC name: 2-amino-5-{2-bromo-8-oxo-1H,4H,5H,6H,7H,8H-pyrrolo[2,3-c]azepin-4-ylidene}-4,5-dihydro-1H-imidazol-4-one; methanol
• IUPAC Traditional name: 2-amino-5-{2-bromo-8-oxo-1H,5H,6H,7H-pyrrolo[2,3-c]azepin-4-ylidene}-1H-imidazol-4-one; methanol
• Synonyms: (4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-pyrrolo[2,3-c]azepin-8(1H)-one Methanoate; (Z)-Hymenialdisine Methanoate

DATABASE IDS

• CAS Number: 84094-94-0

PROPERTIES

• Apperance: Light Yellow Solid
• Melting Point: >245°C (dec.)
• Solubility: DMSO
• Storage Condition: Freezer

DETAILS

Description (English)

A potent inhibitor of a variety of kinases including MEK-1, GSK-3Β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations. A marine sponge alkaloid, a natural product.

REFERENCES

• Cheetham, G., et al.: J. Biol. Chem., 277, 42419 (2002)
• Bain, J., et al.: Biochem. J., 371, 199 (2002)
• Sharma, V., et al.: Bioorg. Med. Chem. Lett., 14, 4319 (2002)
• Anamika, et al.: Proteins, 58, 180 (2002)
• Birault, V., et al.: Curr. Med. Chem., 13, 1