42-O-[2-[[Hydroxy[2-(trimethylammonio)ethoxy]phosphinyl]oxy]ethyl] Rapamycin Inner Salt >75%

• Catalog No.: H972100
• CAS Number: 1062645-51-5
• M. F.: C58H95N2O17P
• M. W.: 1123.351861
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 2-{[(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30R,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl]oxy}ethyl 2-(trimethylazaniumyl)ethyl phosphate
• IUPAC Traditional name: 2-{[(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30R,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl]oxy}ethyl 2-(trimethylammonio)ethyl phosphate
• Synonyms: ATG 181

DATABASE IDS

• CAS Number: 1062645-51-5

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 135-140°C
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A phosphocholine ester metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin (R124000).

REFERENCES

• Zollinger, M. et al.: Drug. Metab. Disp., 36, 1457 (2008)
• Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2008)