4-Hydroxy Tamoxifen N-β-D-Glucuronide(E/Z-Mixture)

• Catalog No.: H954740
• M. F.: C32H38NO8+
• M. W.: 564.64602
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-N-(2-{4-[1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)-N,N-dimethyloxan-2-aminium
• IUPAC Traditional name: (2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-N-(2-{4-[1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)-N,N-dimethyloxan-2-aminium
• Synonyms: N-β-D-Glucopyranuronosyl-2-[4-[(1E/Z)-1-(4-hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanaminium; 4-OH-TAM-N-Glucuronide

PROPERTIES

• Apperance: White Solid
• Melting Point: 149-151°C (dec.)
• Solubility: Methanol
• Solubility: Water
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A glucuronide of (Z)-4-Hydroxy Tamoxifen (or trans-4-hydroxytamoxifen), an active metabolite of Tamoxifen (T006000).

REFERENCES

• Beaulieu, M., et al.: J. Biol. Chem., 271, 22855 (1996)
• Green, M., et al.: Drug Metab. Dispos., 26, 860 (1996)
• Nishiyama, T., et al.: Biochem. Pharmacol., 63, 1817 (1996)