3'-p-Hydroxy Paclitaxel

• Catalog No.: H948895
• CAS Number: 132160-32-8
• M. F.: C47H51NO15
• M. W.: 869.90554
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-(4-hydroxyphenyl)-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^3,^1^0.0^4,^7]heptadec-13-en-2-yl benzoate
• IUPAC Traditional name: (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-(4-hydroxyphenyl)-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^3,^1^0.0^4,^7]heptadec-13-en-2-yl benzoate
• Synonyms: 3'-Para-hydroxypaclitaxel; [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α,4-dihydroxy-benzenepropanoic Acid 6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-4-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester

DATABASE IDS

• CAS Number: 132160-32-8

PROPERTIES

• Apperance: White Solid
• Melting Point: 182-184°C
• Solubility: Chloroform
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A metabolite of Paclitaxel; a phase I pharmacokinetic study in patients with solid tumors.

REFERENCES

• Sonnichsen, D., et al.: J. Pharmacol. Exp. Ther., 275, 566 (1995)
• Walle, T., et al.: Drug Metab. Dispos., 23, 506 (1995)
• Torres, K., et al.: Cancer Res., 58, 3620 (1995)
• Svojanovsky, S., et al.: J. Pharm. Biomed. Anal., 20, 549 (1995)