4-(Hydroxymethyl)-2'-thymidine-d2 Tri(tert-butyldimethylsilyl) Triether

• Catalog No.: H946637
• M. F.: C28H56N2O6Si3
• M. W.: 601.01054
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 5-{[(tert-butyldimethylsilyl)oxy](^2H₂)methyl}-1-[(2R,4S,5R)-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
• IUPAC Traditional name: 5-{[(tert-butyldimethylsilyl)oxy](^2H₂)methyl}-1-[(2R,4S,5R)-4-[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-2-yl]-3H-pyrimidine-2,4-dione
• Synonyms: 3',5'-Bis-O-[(1,1-dimethylethyl)dimethylsilyl]-α-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-thymidine-d2

PROPERTIES

• Apperance: Colorless Foam
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: Dimethyl Formamide
• Solubility: Ethanol
• Solubility: Ethyl Acetate
• Storage Condition: Refrigerator

DETAILS

Description (English)

Used in the preparation of 5-modified-2'-dU and 2'-dC as mutagenic anti HIV-1 proliferation agents.

REFERENCES

• El Safadi, Y. et al.; J. Med. Chem. 53, 1534 (2010)