Hydroxymethyl Dasatinib_Molecular_structure_CAS_910297-58-4)

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Hydroxymethyl Dasatinib
Catalog No.	H946625	Name	Toronto Research Chemicals
CAS Number	910297-58-4	Website	http://www.trc-canada.com
M. F.	C22H26ClN7O3S	Telephone	+1 (416) 665-9696
M. W.	504.00494	Fax	+1 (416) 665-4439
Purity		Email	info@trc-canada.com
Storage	Refrigerator	Chembase ID: 170789

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SYNONYMS

IUPAC name

N-[2-chloro-6-(hydroxymethyl)phenyl]-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide

IUPAC Traditional name

N-[2-chloro-6-(hydroxymethyl)phenyl]-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide

Synonyms

N-[2-Chloro-6-(hydroxymethyl)phenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide

DATABASE IDS

CAS Number

910297-58-4

PROPERTIES

Certificate of Analysis	Download
Apperance	White to Off-White Solid
Melting Point	191-195°C
Solubility	DMSO
Solubility	Methanol
MSDS Link	Download
Storage Condition	Refrigerator

DETAILS

Description (English)

An oxidative metabolite of Dasatinib (M24 metabolite); used in the treatment of cancers and immune diseases.

REFERENCES

Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991)
Shah, N., et al.: Science, 305, 399 (1991)
O'Hare, T., et al.: Cancer Res., 65, 4500 (1991)
Das, J., et al.: J. Med. Chem., 49, 6819 (1991)
Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008