4-Hydroxy Estrone 1-N7-Guanine

• Catalog No.: H942120
• CAS Number: 178971-92-1
• M. F.: C23H25N5O4
• M. W.: 435.4757

SYNONYMS

• IUPAC name: 2-amino-7-[(1S,10R,11S,15S)-5,6-dihydroxy-15-methyl-14-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-trien-3-yl]-6,7-dihydro-1H-purin-6-one
• IUPAC Traditional name: 2-amino-7-[(1S,10R,11S,15S)-5,6-dihydroxy-15-methyl-14-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-trien-3-yl]-1H-purin-6-one
• Synonyms: 2-Amino-7-(3,4-dihydroxy-17-oxoestra-1,3,5(10)-trien-1-yl)-1,7-dihydro-6H-purin-6-one; 4-OH-E1-1-N7Gua

DATABASE IDS

• CAS Number: 178971-92-1

DETAILS

Description (English)

4-Hydroxy Estrone 1-N7-Guanine is an estrogen metabolite formed with DNA which can lead to the mutations that initiate breast, prostate, and other types of cancer. Estrogen-DNA depurinating adducts as biomarkers of cancer risk and their use in cancer dete

REFERENCES

• Chakravarti, D., et al.: Mutat. Res., 456, 17 (2000)
• Liehr, J., et al.: Endocr. Rev., 21, 4054 (2000)
• Chakravarti, D., et al.: Oncogene, 20, 7945 (2000)
• Cavalieri, E., et al.: Chem. Res. Toxicol., 14, 1041 (2000)