4-Hydroxy Estradiol 1-N3-Adenine

• Catalog No.: H942100
• CAS Number: 428506-88-1
• M. F.: C23H27N5O3
• M. W.: 421.49218

SYNONYMS

• IUPAC name: (1S,10R,11S,14S,15S)-3-(6-amino-3H-purin-3-yl)-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-triene-5,6,14-triol
• IUPAC Traditional name: (1S,10R,11S,14S,15S)-3-(6-aminopurin-3-yl)-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-triene-5,6,14-triol
• Synonyms: 4-OH-E2-1-N3Ade; (17β)-1-(6-Amino-3H-purin-3-yl)estra-1,3,5(10)-triene-3,4,17-triol

DATABASE IDS

• CAS Number: 428506-88-1

DETAILS

Description (English)

4-Hydroxy Estradiol 1-N3-Adenine is an estrogen metabolite formed with DNA which can lead to the mutations that initiate breast, prostate, and other types of cancer. The N3Ade depurinating adducts could serve as biomarkers to predict the risk of breast ca

REFERENCES

• Chakravarti, D., et al.: Mutat. Res., 456, 17 (2000)
• Liehr, J., et al.: Endocr. Rev., 21, 4054 (2000)
• Chakravarti, D., et al.: Oncogene, 20, 7945 (2000)
• Cavalieri, E., et al.: Chem. Res. Toxicol., 14, 1041 (2000)