N-(2-Hydroxyethyl)-11-azaartemisinin

• Catalog No.: H941970
• CAS Number: 255731-00-1
• M. F.: C17H27NO5
• M. W.: 325.39998

SYNONYMS

• IUPAC name: (1S,4S,5R,8S,9R,12R)-11-(2-hydroxyethyl)-1,5,9-trimethyl-14,15,16-trioxa-11-azatetracyclo[10.3.1.0^4,^1^3.0^8,^1^3]hexadecan-10-one
• IUPAC Traditional name: (1S,4S,5R,8S,9R,12R)-11-(2-hydroxyethyl)-1,5,9-trimethyl-14,15,16-trioxa-11-azatetracyclo[10.3.1.0^4,^1^3.0^8,^1^3]hexadecan-10-one
• Synonyms: (3R,5aS,6R,8aS,9R,12R,12aR)-Decahydro-11-(2-hydroxyethyl)-3,6,9-trimethyl-3,12-epoxy-1,2-dioxepino[4,3-i]isoquinolin-10(3H)-one

DATABASE IDS

• CAS Number: 255731-00-1

DETAILS

Description (English)

A derivative of 11-Azaartemisinin which showed a high order of activity against multidrug-resistant malaria by oral route.

REFERENCES

• Meshnick, S.R., et al.: Microbiol. Rev., 60, 301 (1996)
• O’Neill, P.M., et al.: J. Med. Chem., 45, 1052 (1996)
• Rottmann, M., et al.: J. Med. Chem., 51, 1035 (1996)