rac 8-Hydroxy Efavirenz-d4

• Catalog No.: H941827
• M. F.: C14H9ClF3NO3
• M. W.: 331.6743696
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (4S)-6-chloro-4-{2-[(2,2,3,3-^2H₄)cyclopropyl]ethynyl}-8-hydroxy-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one
• IUPAC Traditional name: (4S)-6-chloro-4-{2-[(2,2,3,3-^2H₄)cyclopropyl]ethynyl}-8-hydroxy-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
• Synonyms: 6-Chloro-4-(cyclopropyl-d4-ethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one; 8-Hydroxyefavirenz

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 144-154°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A labellebed metabolite of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor.

REFERENCES

• Gorski, J., et al.: Biochem. Pharmacol., 47, 1643 (1994)
• Desta, Z., et al.: J. Pharmacol. Exp. Ther., 285, 428 (1994)
• Langmann, P., et al.: Eur. J. Med. Res., 7, 309(1994)
• Chang, T., et al.: Drug Metab. Dispos., 31, 7 (1994)