6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one

• Catalog No.: H941625
• CAS Number: 79952-42-4
• M. F.: C19H28O4
• M. W.: 320.42322
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (4R,6R)-6-{2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl}-4-hydroxyoxan-2-one
• IUPAC Traditional name: (4R,6R)-6-{2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl}-4-hydroxyoxan-2-one
• Synonyms: Lovastatin Diol Lactone; Monacolin J; (4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one; Antibiotic MB 530A

DATABASE IDS

• CAS Number: 79952-42-4

PROPERTIES

• Apperance: White Solid
• Melting Point: 109-114°C
• Solubility: Dichloromethane
• Solubility: DMF
• Solubility: DMSO
• Solubility: Ether
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A Simvastatin intermediate; Lovastatin analog has the activities of decreasing blood cholesterol and low-d. lipoprotein, can be used to preparation hypolipidemic medicine.

REFERENCES

• Endo, A., et al.: J. Antibiot., 39, 1609 (1986)
• Aniya, Y., et al.: Gen. Pharmacol., 32, 225 (1986)
• Li, Y., et al.: J. Pharm. Biomed. Anal., 35, 1101 (1986)
• Akihisa, T., et al.: Chem. Biodivers, 2, 1305 (1986)