2-Hydroxyisoquinoline-1,3(2H,4H)-dione

• Catalog No.: H939800
• CAS Number: 6890-08-0
• M. F.: C9H7NO3
• M. W.: 177.15678
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 2-hydroxy-1,2,3,4-tetrahydroisoquinoline-1,3-dione
• IUPAC Traditional name: 2-hydroxy-4H-isoquinoline-1,3-dione
• Synonyms: 2-Hydroxy-1,3(2H,4H)-isoquinolinedione

DATABASE IDS

• CAS Number: 6890-08-0

PROPERTIES

• Apperance: Brown Solid
• Melting Point: 197-200°C
• Solubility: DMSO
• Storage Condition: Refrigerator

DETAILS

Description (English)

2-Hydroxyisoquinoline-1,3(2H,4H)-dione was recently discovered as a scaffold for the inhibition of HIV-1 integrase and the RNase H function of HIV-1 reverse transcriptase. It was investigated its interaction with Mg2+ and Mn2+ using different spectroscopi

REFERENCES

• Greenwald, J., et al.: Biochemistry, 38, 8892 (1999)
• Tramontano, E., et al.: Antiviral Res., 65, 117 (1999)
• Schultz, S., et al.: Virus Res., 134, 86 (1999)
• Williams, P., et al.: Bioorg. Med. Chem. Lett., 22, 6754 (1999)