(Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer)_Molecular_structure_CAS_112093-28-4)

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(Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer)
Catalog No.	H938500	Name	Toronto Research Chemicals
CAS Number	112093-28-4	Website	http://www.trc-canada.com
M. F.	C25H27NO2	Telephone	+1 (416) 665-9696
M. W.	373.48738	Fax	+1 (416) 665-4439
Purity		Email	info@trc-canada.com
Storage	Amber Vial, -86°C Freezer, Under Inert Atmosphere	Chembase ID: 166507

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SYNONYMS

IUPAC name

4-[(1Z)-1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol

IUPAC Traditional name

endoxifen

Synonyms

4-[(1Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol

Endoxifen

DATABASE IDS

CAS Number

112093-28-4

PROPERTIES

Solubility	Chloroform
Solubility	Methanol
Apperance	Off-White to Pink Solid
Melting Point	127-129°C
MSDS Link	Download
Storage Condition	Amber Vial, -86°C Freezer, Under Inert Atmosphere
Certificate of Analysis	Download

DETAILS

Description (English)

A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breas

REFERENCES

Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984)
Leonessa, F., et al.: Cancer Res., 54, 441 (1984)
Stearns, V., et al.: Lancet, 360, 1851 (1984)
Rae, J., et al.: Pharmacogenetics, 13, 501 (1984)