(E)-4-Hydroxy-N-desmethyl Tamoxifen

• Catalog No.: H938495
• CAS Number: 114828-90-9
• M. F.: C25H27NO2
• M. W.: 373.48738
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 4-[(1E)-1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol
• IUPAC Traditional name: 4-[(1E)-1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol
• Synonyms: E-Endoxifen; 4-[(1E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol

DATABASE IDS

• CAS Number: 114828-90-9

PROPERTIES

• Apperance: White Solid
• Melting Point: 154-156°C
• Solubility: Chloroform
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breas

REFERENCES

• Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984)
• Leonessa, F., et al.: Cancer Res., 54, 441 (1984)
• Stearns, V., et al.: Lancet, 360, 1851 (1984)
• Rae, J., et al.: Pharmacogenetics, 13, 501 (1984)