22α-Hydroxy Cholesterol

• Catalog No.: H918015
• CAS Number: 17954-98-2
• M. F.: C27H46O2
• M. W.: 402.65294

SYNONYMS

• IUPAC name: (1S,2R,5S,10S,11S,14R,15S)-14-[(2S,3R)-3-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-7-en-5-ol
• IUPAC Traditional name: 22R-hydroxycholesterol
• Synonyms: Narthesterol; 22α-Hydroxycholesterol; (22R)-Hydroxycholesterol; (3β,22R)-Cholest-5-ene-3,22-diol; (20S,22R)-Cholest-5-ene-3β,22-diol; (22R)-22-Hydroxycholesterol; (22R)-Cholest-5-ene-3β,22-diol; Cholest-5-ene-3β,22(R)-diol

DATABASE IDS

• CAS Number: 17954-98-2

DETAILS

Description (English)

The 22R-metabolite of Cholesterol (C432501). 22-Hydroxycholesterol inhibits chemokine receptor activity.

REFERENCES

• Samson, M., et al.: J. Biol. Chem., 272, 24934 (1997)
• Mackay, C., et al.: Nature Immunol., 2, 95 (1997)
• Navenot, J., et al.: J. Mol. Biol., 313, 1181 (1997)