4β-Hydroxy Cholesterol-d4 (Major)

• Catalog No.: H917983
• M. F.: C27H46O2
• M. W.: 402.65294
• Storage: Refrigerator

SYNONYMS

• IUPAC name: (1S,2R,5S,6R,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methyl(6,7,7,7-^2H₄)heptan-2-yl]tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-7-ene-5,6-diol
• IUPAC Traditional name: (1S,2R,5S,6R,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methyl(6,7,7,7-^2H₄)heptan-2-yl]tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-7-ene-5,6-diol
• Synonyms: Cholest-5-ene-3β,4β-diol-d4; cis-5-Cholestene-3,4-diol-d4; 3β,4β-Dihydroxycholest-5-ene-d4; (3β,4β)-Cholest-5-ene-3,4-diol-d4; cis-3,4-Dihydroxy-5-cholestene-d4

PROPERTIES

• Apperance: Pale Pink Solid
• Melting Point: 172-174°C
• Solubility: Chloroform
• Solubility: Ethyl Acetate
• Storage Condition: Refrigerator

DETAILS

Description (English)

4β-Hydroxy Cholesterol-d4 is a labelled metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.

REFERENCES

• Breuer, O., et al.: J. Lipid Res., 36, 2275 (1995)
• Pikuleva, I., et al.: J. Biol. Chem., 273, 18153 (1995)
• Chawla, A., et al.: Science, 294, 1866 (1995)
• Bodin, K., et al.: J. Biol. Chem., 276, 38685 (1995)