11α-Hydroxy Canrenone

• Catalog No.: H883500
• CAS Number: 192569-17-8
• M. F.: C22H28O4
• M. W.: 356.45532
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (2R,2'R,15'S,17'R)-17'-hydroxy-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecane]-6',8'-diene-5,5'-dione
• IUPAC Traditional name: (2R,2'R,15'S,17'R)-17'-hydroxy-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecane]-6',8'-diene-5,5'-dione
• Synonyms: (11α,17α)-11,17-Dihydroxy-3-oxopregna-4,6-diene-21-carboxylic Acid γ-Lactone

DATABASE IDS

• CAS Number: 192569-17-8

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 232-234°C
• Solubility: Acetone
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

11α-Hydroxy Canrenone is the key intermediate in the synthesis of Eplerenone, a cardiovascular drug. Canrenone was biotransformed into 11α-Hydroxycanrenone by Aspergillus ochraceus SIT34205.

REFERENCES

• Luetscher, J., et al.: J. Clin. Invest., 29, 1576 (1950)
• Gaunt, R., et al.: J. Clin. Endocrinol. Metab., 15, 621 (1950)
• McMahon, E., et al.: Curr. Opin. Pharm., 1, 190 (1950)
• McMahon, E., et al.: Curr. Pharm. Des., 9, 1065 (1950)