Hydroxy Bosentan-d4

• Catalog No.: H830272
• CAS Number: 1065472-91-4
• M. F.: C27H29N5O7S
• M. W.: 567.61346
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: N-{6-[2-hydroxy(^2H₄)ethoxy]-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl}-4-(1-hydroxy-2-methylpropan-2-yl)benzene-1-sulfonamide
• IUPAC Traditional name: N-{6-[2-hydroxy(^2H₄)ethoxy]-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl}-4-(1-hydroxy-2-methylpropan-2-yl)benzenesulfonamide
• Synonyms: Ro 48-8634-d4; 4-(2-Hydroxy-1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy-d4)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide; Ro 48-5033-d4

DATABASE IDS

• CAS Number: 1065472-91-4

PROPERTIES

• Apperance: White Solid
• Melting Point: 124-127°C
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A labelled analogue of the active metabolite of Bosentan, a mixed endothelin receptor antagonist which is used as a vasodilator.

REFERENCES

• Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994)
• Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1994)
• Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1994)
• Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)