Hydroxy Bosentan

• Catalog No.: H830270
• CAS Number: 253688-60-7
• M. F.: C27H29N5O7S
• M. W.: 567.61346
• Storage: -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: 4-(1-hydroxy-2-methylpropan-2-yl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide
• IUPAC Traditional name: 4-(1-hydroxy-2-methylpropan-2-yl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzenesulfonamide
• Synonyms: Ro 48-8634; Ro 48-5033; 4-(2-Hydroxy-1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide

DATABASE IDS

• CAS Number: 253688-60-7

PROPERTIES

• Apperance: White Solid
• Melting Point: 128-132°C
• Solubility: Methanol
• Storage Condition: -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

The active metabolite of Bosentan, a mixed endothelin receptor antagonist which is used as a vasodilator.

REFERENCES

• Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994)
• Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1994)
• Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1994)
• Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)