4-Hydroxy Atorvastatin-d5 Disodium Salt

• Catalog No.: H828962
• M. F.: C33H33FN2Na2O6
• M. W.: 618.6028632
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: disodium (3R,5R)-7-[2-(4-fluorophenyl)-4-[(4-oxidophenyl)carbamoyl]-3-(^2H₅)phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate
• IUPAC Traditional name: disodium (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-4-[(4-oxidophenyl)carbamoyl]-3-(^2H₅)phenylpyrrol-1-yl]-3,5-dihydroxyheptanoate
• Synonyms: PD 142542; (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-4-[[(4-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrole-1-heptanoic Acid Disodium Salt; BMS 241423-01; p-Hydroxyatorvastatin

PROPERTIES

• Apperance: Brown Solid
• Melting Point: 199-203°C
• Solubility: Methanol
• Solubility: Water
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A deuterated metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterole

REFERENCES

• Jacobsen, W., et al.: Drug Metab. Dispos., 28, 1369 (1997)
• Istvan, E., et al.: Science, 292, 1160 (1997)
• Tabernero, L., et al.: J. Biol. Chem., 278, 19933 (1997)
• Bratton, L., et al.: Bioorg. Med. Chem
• Smith, S., et al.: Am. J. Cardiol., 80, 10H (1997)