4-Hydroxy Atorvastatin Calcium Salt

• Catalog No.: H828961
• M. F.: C33H33CaFN2O6
• M. W.: 612.7013232
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: calcium (3R,5R)-7-[2-(4-fluorophenyl)-4-[(4-oxidophenyl)carbamoyl]-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate
• IUPAC Traditional name: calcium (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-4-[(4-oxidophenyl)carbamoyl]-3-phenylpyrrol-1-yl]-3,5-dihydroxyheptanoate
• Synonyms: (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-4-[[(4-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrole-1-heptanoic Acid Calcium Salt; p-Hydroxyatorvastatin Calcium Salt

PROPERTIES

• Apperance: Light Beige Solid
• Melting Point: 181-186°C
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

4-Hydroxyatorvastatin is a hydroxylated metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in pati

REFERENCES

• Smith, S. et al.: Am. J. Cardiol., 80, 10H (1997)
• Jacobsen, W. et al.: Drug Metab. Dispos., 28, 1369 (1997)
• Istvan, E. et al.: Science, 292, 1160 (1997)
• Tabernero, L. et al.: J. Biol. Chem., 278, 19933 (1997)
• Bratton, L. et al.: Bioorg. Med. Chem., 15