2-Hydroxy Atorvastatin-d5 Disodium Salt

• Catalog No.: H828952
• CAS Number: 1276537-19-9
• M. F.: C33H33FN2Na2O6
• M. W.: 618.6028632
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: disodium (3R,5R)-7-[2-(4-fluorophenyl)-4-[(2-oxidophenyl)carbamoyl]-3-(^2H₅)phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate
• IUPAC Traditional name: disodium (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-4-[(2-oxidophenyl)carbamoyl]-3-(^2H₅)phenylpyrrol-1-yl]-3,5-dihydroxyheptanoate
• Synonyms: o-Hydroxyatorvastatin Disodium Salt; PD 152873; (βR,δR)-2-(4-fluorophenyl)-β,δ-dihydroxy-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-(phenyl-d5)-1H-pyrrole-1-heptanoic Acid Disodium Salt; BMS 243887-01

DATABASE IDS

• CAS Number: 1276537-19-9

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 132-134°C
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A deuterated metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterole

REFERENCES

• Smith, S., et al.: Am. J. Cardiol., 80, 10H (1997)
• Jacobsen, W., et al.: Drug Metab. Dispos., 28, 1369 (1997)
• Istvan, E., et al.: Science, 292, 1160 (1997)
• Tabernero, L., et al.: J. Biol. Chem., 278, 19933 (1997)
• Bratton, L., et al.: Bioorg. Med. Chem