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2-Hydroxy Atorvastatin-d5 Disodium Salt_Molecular_structure_CAS_1276537-19-9)
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2-Hydroxy Atorvastatin-d5 Disodium Salt

Catalog No. H828952 Name Toronto Research Chemicals
CAS Number 1276537-19-9 Website http://www.trc-canada.com
M. F. C33H33FN2Na2O6 Telephone +1 (416) 665-9696
M. W. 618.6028632 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Hygroscopic, -20°C Freezer, Under Inert Atmosphere Chembase ID: 170255

SYNONYMS

IUPAC name
disodium (3R,5R)-7-[2-(4-fluorophenyl)-4-[(2-oxidophenyl)carbamoyl]-3-(2H5)phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate
IUPAC Traditional name
disodium (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-4-[(2-oxidophenyl)carbamoyl]-3-(2H5)phenylpyrrol-1-yl]-3,5-dihydroxyheptanoate
Synonyms
o-Hydroxyatorvastatin Disodium Salt
PD 152873
(βR,δR)-2-(4-fluorophenyl)-β,δ-dihydroxy-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-(phenyl-d5)-1H-pyrrole-1-heptanoic Acid Disodium Salt
BMS 243887-01

DATABASE IDS

CAS Number 1276537-19-9

PROPERTIES

Certificate of Analysis Download
Apperance Yellow Solid
Melting Point 132-134°C
Solubility Methanol
MSDS Link Download
Storage Condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)
A deuterated metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterole

REFERENCES

  • Smith, S., et al.: Am. J. Cardiol., 80, 10H (1997)
  • Jacobsen, W., et al.: Drug Metab. Dispos., 28, 1369 (1997)
  • Istvan, E., et al.: Science, 292, 1160 (1997)
  • Tabernero, L., et al.: J. Biol. Chem., 278, 19933 (1997)
  • Bratton, L., et al.: Bioorg. Med. Chem