Hydroxocobalamin Acetate

• Catalog No.: H826800
• CAS Number: 22465-48-1
• M. F.: C64H91CoN13O16P
• M. W.: 1388.391801
• Storage: Refrigerator

SYNONYMS

• IUPAC name: (acetyloxy)[(6Z,16Z)-4,9,14-tris(2-carbamoylethyl)-3,8,19-tris(carbamoylmethyl)-18-{2-[(2-{[(2R,3S,4R,5S)-5-(5,6-dimethyl-1H-1,3-benzodiazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl phosphonato]oxy}propyl)carbamoyl]ethyl}-2,3,6,8,13,13,16,18-octamethyl-20,21,22,23-tetraazapentacyclo[15.2.1.1^2,^5.1^7,^1^0.1^1^2,^1^5]tricosa-5(23),6,10(22),11,15(21),16-hexaen-20-yl]cobaltylium
• IUPAC Traditional name: (acetyloxy)[(6Z,16Z)-4,9,14-tris(2-carbamoylethyl)-3,8,19-tris(carbamoylmethyl)-18-{2-[(2-{[(2R,3S,4R,5S)-5-(5,6-dimethyl-1,3-benzodiazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl phosphonato]oxy}propyl)carbamoyl]ethyl}-2,3,6,8,13,13,16,18-octamethyl-20,21,22,23-tetraazapentacyclo[15.2.1.1^2,^5.1^7,^1^0.1^1^2,^1^5]tricosa-5(23),6,10(22),11,15(21),16-hexaen-20-yl]cobaltylium
• Synonyms: Acetatocobalamin; Fresmin S; Depo-gamma; Twelvmin; Cobinamide Acetate (Salt) Dihydrogen Phosphate (Ester) Inner Salt 3'-Ester with 5,6-Dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole; Docelan; Novidroxin

DATABASE IDS

• CAS Number: 22465-48-1

PROPERTIES

• Apperance: Dark-Red Solid
• Melting Point: >300°C.
• Solubility: Methanol
• Solubility: Water
• Storage Condition: Refrigerator

DETAILS

Description (English)

Physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide.

REFERENCES

• Kaczka, E.A., et al.: Science, 112, 354 (1950)
• Friedrich, W., et al.: Vitamins, 837 (1950)
• Forsyth, J.C., et al.: Clin. Toxicol., 31, 277 (1950)