(-)-Huperzine A

• Catalog No.: H826000
• CAS Number: 102518-79-6
• M. F.: C15H18N2O
• M. W.: 242.31622
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (1R)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0^2,^7]trideca-2(7),3,10-trien-5-one
• IUPAC Traditional name: (1R)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0^2,^7]trideca-2(7),3,10-trien-5-one
• Synonyms: [5R-(5α,9β-11E)]-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2-(1H)-one; Selagine,; HUP

DATABASE IDS

• CAS Number: 102518-79-6

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 223-226°C (dec.)
• Solubility: DMSO
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier. A potential therapeutic agent for Alzheimer’s disease. It reduces cell death induced by glutamate in primary cultures derived from forebrain, hippocampus, cortex and cerebellum

REFERENCES

• Wang, Y.-E., et al.: Acta Pharmacol. Sin., 7, 110 (1986)
• Ved, H.S., et al.: Neuroreport, 8, 963 (1997)