(19E/Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin Sodium Salt >80%

• Catalog No.: H825290
• M. F.: C53H82NNaO14
• M. W.: 980.20625
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: sodium (2S)-1-{2-[(2R,3R,6S)-2-hydroxy-6-[(2R,3E,5E,7E,9S,11R,13R,14R,15E,17R,19E,21R)-14-hydroxy-21-{[(1S,3S,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]methyl}-2,13-dimethoxy-3,9,11,15,17-pentamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl]-3-methyloxan-2-yl]-2-oxoacetyl}piperidine-2-carboxylate
• IUPAC Traditional name: sodium (2S)-1-{2-[(2R,3R,6S)-2-hydroxy-6-[(2R,3E,5E,7E,9S,11R,13R,14R,15E,17R,19E,21R)-14-hydroxy-21-{[(1S,3S,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]methyl}-2,13-dimethoxy-3,9,11,15,17-pentamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl]-3-methyloxan-2-yl]-2-oxoacetyl}piperidine-2-carboxylate
• Synonyms: (2S)-1-[2-oxo-2-[(2R,3R,6S)-tetrahydro-2-hydroxy-6-[(2S,3E,5E,7E,9S,11R,13R,14R,15E,17R,19E/Z,21R)-14-hydroxy-22-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxo-3,5,7,15,19-docosapentaen-1-yl]-3-methyl-2H-pyran-2-yl]acetyl]-2-piperidinecarboxylic Acid Sodium Salt; seco Everolimus Sodium Salt

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 95-100°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin (R124000).

REFERENCES

• Vidal, C. et al.: J. Am. Soc. Mass Spec., 9, 1267 (1998)
• Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (1998)