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4'-Hydroxy DasatinibDiscontinued_Molecular_structure_CAS_910297-57-3)
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4'-Hydroxy DasatinibDiscontinued

Catalog No. H825200 Name Toronto Research Chemicals
CAS Number 910297-57-3 Website http://www.trc-canada.com
M. F. C22H26ClN7O3S Telephone +1 (416) 665-9696
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SYNONYMS

IUPAC name
N-(2-chloro-4-hydroxy-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide
IUPAC Traditional name
N-(2-chloro-4-hydroxy-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide
Synonyms
N-(2-Chloro-4-hydroxy-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide

DATABASE IDS

CAS Number 910297-57-3

PROPERTIES

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DETAILS

Description (English)
An oxidative metabolite of Dasatinib (M20 metabolite); used in the treatment of cancers and immune diseases.

REFERENCES

  • Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991)
  • Shah, N., et al.: Science, 305, 399 (1991)
  • O'Hare, T., et al.: Cancer Res., 65, 4500 (1991)
  • Das, J., et al.: J. Med. Chem., 49, 6819 (1991)
  • Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (200