N-Hydroxy-11-azaartemisinin

• Catalog No.: H804500
• CAS Number: 1086409-82-6
• M. F.: C15H23NO5
• M. W.: 297.34682
• Storage: Amber Vial, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (1S,4S,5R,8S,9R,12R)-11-hydroxy-1,5,9-trimethyl-14,15,16-trioxa-11-azatetracyclo[10.3.1.0^4,^1^3.0^8,^1^3]hexadecan-10-one
• IUPAC Traditional name: (1S,4S,5R,8S,9R,12R)-11-hydroxy-1,5,9-trimethyl-14,15,16-trioxa-11-azatetracyclo[10.3.1.0^4,^1^3.0^8,^1^3]hexadecan-10-one
• Synonyms: (3R,5aS,6R,8aS,9R,12R,12aR)-11-Hydroxydecahydro-3,6,9-trimethyl-3,12-epoxy-1,2-dioxepino[4,3-i]isoquinolin-10(3H)-one

DATABASE IDS

• CAS Number: 1086409-82-6

PROPERTIES

• Apperance: White Solid
• Melting Point: 187-190°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Amber Vial, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A derivative of 11-Azaartemisinin which showed a high order of activity against multidrug-resistant malaria by oral route.

REFERENCES

• Meshnick, S.R., et al.: Microbiol. Rev., 60, 301 (1996)
• O’Neill, P.M., et al.: J. Med. Chem., 45, 1052 (1996)
• Rottmann, M., et al.: J. Med. Chem., 51, 1035 (1996)