Hydrocortisone 17-Propionate 21-Acetate

• Catalog No.: H714628
• CAS Number: 74050-20-7
• M. F.: C26H36O7
• M. W.: 460.55984
• Storage: Refrigerator

SYNONYMS

• IUPAC name: (1S,2R,10S,11S,14R,15S,17S)-14-[2-(acetyloxy)acetyl]-17-hydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-6-en-14-yl propanoate
• IUPAC Traditional name: hydrocortisone aceponate
• Synonyms: Cortisol 17-Propionate 21-Acetate; (11β)-21-(Acetyloxy)-11-hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione; Hydrocortisone Aceponate

DATABASE IDS

• CAS Number: 74050-20-7

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 144-146°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

A new topical hydrocortisone derivative with esterification in positions 17 and 21, inhibit the incorporation of [3H]thymidine in DNA in human skin fibroblasts less strongly than the halogenated glucocorticosteroids betamethasone 17-valerate and clobetaso

REFERENCES

• Dooms-Goossens, A., et al.: Eur. J. Dermatol., 3, 713 (1993)
• Isaksson, M., et al.: Contact Dermatitis, 43, 41 (1993)
• Matura, M., et al.: Allergy, 55, 698 (1993)