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Hydrocortisone 17-Propionate 21-Acetate_Molecular_structure_CAS_74050-20-7)
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Hydrocortisone 17-Propionate 21-Acetate

Catalog No. H714628 Name Toronto Research Chemicals
CAS Number 74050-20-7 Website http://www.trc-canada.com
M. F. C26H36O7 Telephone +1 (416) 665-9696
M. W. 460.55984 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Refrigerator Chembase ID: 170048

SYNONYMS

IUPAC name
(1S,2R,10S,11S,14R,15S,17S)-14-[2-(acetyloxy)acetyl]-17-hydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0.02,7.011,15]heptadec-6-en-14-yl propanoate
IUPAC Traditional name
hydrocortisone aceponate
Synonyms
Cortisol 17-Propionate 21-Acetate
(11β)-21-(Acetyloxy)-11-hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione
Hydrocortisone Aceponate

DATABASE IDS

CAS Number 74050-20-7

PROPERTIES

Certificate of Analysis Download
Apperance White to Off-White Solid
Melting Point 144-146°C
Solubility Chloroform
Solubility Methanol
MSDS Link Download
Storage Condition Refrigerator

DETAILS

Description (English)
A new topical hydrocortisone derivative with esterification in positions 17 and 21, inhibit the incorporation of [3H]thymidine in DNA in human skin fibroblasts less strongly than the halogenated glucocorticosteroids betamethasone 17-valerate and clobetaso

REFERENCES

  • Dooms-Goossens, A., et al.: Eur. J. Dermatol., 3, 713 (1993)
  • Isaksson, M., et al.: Contact Dermatitis, 43, 41 (1993)
  • Matura, M., et al.: Allergy, 55, 698 (1993)