(2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl Ester 2-Methyl Ester

• Catalog No.: H656560
• CAS Number: 74844-91-0
• M. F.: C11H19NO5
• M. W.: 245.27226

SYNONYMS

• IUPAC name: 1-tert-butyl 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
• IUPAC Traditional name: 1-tert-butyl 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
• Synonyms: N-tert-Butoxycarbonyl-L-hydroxyproline Methyl Ester; 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S-trans)-1-tert-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic Acid Methyl Ester; (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic Acid 1-(1,1-Dimethylethyl) 2-Methyl Ester; (2S,4R)-1-Boc-4-hydroxy-L-proline Methyl Ester; Methyl (4R)-N-Boc-4-hydroxy-L-prolinate

DATABASE IDS

• CAS Number: 74844-91-0

PROPERTIES

• Apperance: Clear Colourless Oil
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: DMF
• Solubility: Ethyl Acetate

DETAILS

Description (English)

(2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl Ester 2-Methyl Ester is used in the synthesis of For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold.

REFERENCES

• Freer, R., et al.: Biochemistry, 21, 257 (1982)
• Higgins, J., et al.: J. Med. Chem., 39, 1013 (1982)
• Cavicchioni, G., et al.; Bioorg. Chem., 34, 298 (1982)
• Selvatici, R., et al.: Eur. J. Pharmacol., 534, 1 (1982)