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(2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl Ester 2-Methyl Ester_Molecular_structure_CAS_74844-91-0)
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(2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl Ester 2-Methyl Ester

Catalog No. H656560 Name Toronto Research Chemicals
CAS Number 74844-91-0 Website http://www.trc-canada.com
M. F. C11H19NO5 Telephone +1 (416) 665-9696
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SYNONYMS

IUPAC name
1-tert-butyl 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
IUPAC Traditional name
1-tert-butyl 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
Synonyms
N-tert-Butoxycarbonyl-L-hydroxyproline Methyl Ester
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S-trans)-1-tert-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic Acid Methyl Ester
(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic Acid 1-(1,1-Dimethylethyl) 2-Methyl Ester
(2S,4R)-1-Boc-4-hydroxy-L-proline Methyl Ester
Methyl (4R)-N-Boc-4-hydroxy-L-prolinate

DATABASE IDS

CAS Number 74844-91-0

PROPERTIES

Certificate of Analysis Download
Apperance Clear Colourless Oil
Solubility Chloroform
Solubility Dichloromethane
Solubility DMF
Solubility Ethyl Acetate
MSDS Link Download

DETAILS

Description (English)
(2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl Ester 2-Methyl Ester is used in the synthesis of For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold.

REFERENCES

  • Freer, R., et al.: Biochemistry, 21, 257 (1982)
  • Higgins, J., et al.: J. Med. Chem., 39, 1013 (1982)
  • Cavicchioni, G., et al.; Bioorg. Chem., 34, 298 (1982)
  • Selvatici, R., et al.: Eur. J. Pharmacol., 534, 1 (1982)