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Homoharringtonine

Catalog No. H596500 Name Toronto Research Chemicals
CAS Number 26833-87-4 Website http://www.trc-canada.com
M. F. C29H39NO9 Telephone +1 (416) 665-9696
M. W. 545.62126 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage -20°C Freezer Chembase ID: 169932

SYNONYMS

IUPAC name
(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl 1-methyl (3R)-3-hydroxy-3-(4-hydroxy-4-methylpentyl)butanedioate
IUPAC Traditional name
omacetaxine mepesuccinate
Synonyms
Ceflatonin
CGX 635
Cephalotaxine 4-Methyl (2R)-2-Hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester)
Myelostat
Omacetaxine Mepesuccinate
NSC 141633

DATABASE IDS

CAS Number 26833-87-4

PROPERTIES

Certificate of Analysis Download
Apperance Off-White Solid
Melting Point 133-135°C
Solubility Chloroform
Solubility Methanol
MSDS Link Download
Storage Condition -20°C Freezer

DETAILS

Description (English)
Homoharringtonine (HHT) combined with some botanical drugs could induce cancer cells to resemble normal cells. HHT was prepared by a semi-synthetic method from Cephalotaxine, a major alkaloid of Cepahlotaxus species through the formation of α-ketoester ha

REFERENCES

  • Baaske, D., et al.: Antimicrob. Agents Chemother., 12, 298 (1977)
  • Tipping, A., et al.: Leukemia, 16, 2349 (1977)
  • Marin, D., et al.: Cancer, 103, 1850 (1977)
  • Levy, V., et al.: Br. J. Cancer, 95, 253 (1977)
  • de Lavallade, H., et al.: Blood, 2779 (1977)